RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.

Nat Commun · 2022 · PMC9120198 · PMID 35589755

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highly significantno p-value reported

Treatment with deltarasin led to a rapid organoid dissociation and a highly significant reduction in viability of both Apc fl/fl and KPN organoid lines demonstrating an important role for KRAS4B in maintaining CRC organoid viability (Fig. 5 e, f ).

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