Barely Significant
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Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect.

Mil Med Res · 2022 · PMC9121578 · PMID 35596191

Europe PMCDOI
1
hedged sentence
0.0500
closest p · 1.0× alpha
0.0500
boldest claim

The sentences

did not achieve significanceP > 0.05actually significant
Cel inhibits pyruvate kinase activity and the proinflammatory activity of HMGB1 In LPS-activated macrophages, Cel did not significantly affect expression of PKM1 but it did slightly reverse the LPS-induced upregulation of PKM2, although this change did not achieve significance ( P > 0.05, Fig. 5 a, Additional file 1 : Fig.

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