a decreasing trendP < 0.05
3 B), leading to two periods with distinct trends: a decreasing trend between 2009 and 2016 [− 11.46% annual percentage change (APC), P < 0.05], where the proportion of patients with this CD4 + count decreased from 74.29% in 2009 to 35% in 2016 (Fig. 2 ), and an increasing trend between 2016 and 2019 (6.28% APC, nonsignificant), where the proportion of patients with this CD4 + count increased from 35% in 2016 to 36.84% in 2019.