Hospitalization, major complications and mortality in acute myocardial infarction patients during the COVID-19 era: A systematic review and meta-analysis.

Importantly, the in-hospital mortality rate was increased, without statistically significance, among patients admitted with AMI during the COVID-19 pandemic; however, accumulation of data from studies focusing on STEMI and NSTEMI did not show a statistically significance increase in mortality rates, also the rate of major complications of AMI was not significantly different during the pandemic, but demonstrated an increasing trend. 4.1 Understanding the decline in AMI admissions Early in the pandemic, when the first studies reporting a decline in AMI cases came out, speculation started about the potential mechanisms of this concerning observation [8] , [19] , [24] .

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