Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells.

P value<0.05 values were considered statistically significant (*), p value<0.01 values were considered very significant (**), and p value<0.001 values were considered highly significant (***).

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Treg proportions generally followed an increasing trend in the tumor microenvironment in both models from early to advanced disease stage ( figure 1A–D , online supplemental figure S1A–D ).

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