Subnuclear localisation is associated with gene expression more than parental origin at the imprinted Dlk1-Dio3 locus.

PLoS Genet · 2022 · PMC9129038 · PMID 35482825

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highly significantno p-value reported

Discussion We performed 3D RNA-DNA FISH measurements in a total of 18 mouse ES cell lines and observed a very small but overall highly significant effect for Gtl2/Meg3 -expressing alleles of the Dlk1-Dio3 imprinted region to be localized towards the nuclear interior and for non-expressing alleles to be localized towards the nuclear periphery.

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