TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response.

Both cohorts were compared using a Cox survival analysis, that showed a highly significant reduction in patient survival in tumors with TRIB1 mutations (Figure 1 A, HR 0.56 CI 0.50-0.62; lograk p = 4.1×10 -26 ), indicating a worse prognosis for those patients with the transcriptomic signature associated with somatic mutations in the TRIB1 gene.

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