highly significantp <0.001
Fortunately, adopting a co-delivering strategy for DOX⋅HCl and CQ, DC-DIV/C exhibited much stronger anti-tumor efficacy with the TIR of 84.52 %, displaying significant difference (*p<0.05) with free DC (TIR = 71.30%), and highly significant difference (***p <0.001) with D-DIV/C (TIR = 47.70 %).