Identification of an endoplasmic reticulum stress-related signature associated with clinical prognosis and immune therapy in glioma.

Because the UPR not only induces cell apoptosis [ 16 – 18 ] and regulates chemotherapeutic sensitivity [ 19 – 22 ] but also modulates the immune microenvironment and elicits immunogenic cancer cell death(ICD) [ 23 , 24 ], we assumed that detecting ERS-related genes is incredibly significant to evaluate prognosis and the immune microenvironment, contributes to finding prognostic targets and develops more effective therapy sites for glioma.

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