Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods.

When patients with MolNE with negative RQ-PCR and insufficient assay sensitivity were excluded from the analysis, the difference between the OS of the 2 groups remained highly significant (NGS-MRD − patients: n = 26, 5-year OS = 84% ± 9%; NGS-MRD + patients: n = 41, 5-year OS = 37% ± 8%, P = .0024; supplemental Figure 2).

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