A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Rep Med · 2022 · PMC9133403 · PMID 35584624

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highly significantno p-value reported

Since the univariate t test and Mann-Whitney U tests are testing for differences in central tendencies (i.e., the mean or the median, respectively), the TMB paradox explains why the majority of genes have a highly significant association with elevated TMBs.

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