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Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank.

BMC Med · 2022 · PMC9137080 · PMID 35619136

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a decreasing trendno p-value reported
an increasing trendno p-value reported
An increasing trend in the proportion of neurodegenerative disorders and liver diseases and a decreasing trend in the proportion of cancer was seen with the accumulation of disease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.