Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.

This is considered highly significant, as (1) leucine contained only a single 13 C label (compared with, e.g., UL-glucose), (2) it is one of two strictly ketogenic amino acids along with lysine; further, and (3) there are 5 additional amino acids whose breakdown results in carbons supplying the AcCoA pool and hence acyl chains: phenylalanine, isoleucine, threonine, tryptophan, and tyrosine.

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