highly significantp ≤ 0.01
The protective effect of honey, propolis, and royal jelly treatment was detected in the significant downregulation ( p ≤ 0.05) of the PARP-1 gene expression level, whereas highly significant ( p ≤ 0.01) downregulation was demonstrated after combined treatment of honey, royal jelly, and propolis as compared to the DOX group (4.3, 4.7, 3.9, 2.6, 5.5, respectively).