Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77.

Zooming in on the downstream pathways, EnrichR revealed a highly significant enrichment of TRAF6-mediated IRF7 signaling among the oxLDL differentially expressed pDC genes ( Figure 5 E,F); the relevance of the TRAF6-IRF7 axis was also highlighted in the strong protein–protein interaction network that could be constructed based on the set of top differentially expressed genes ( Supplementary Figure S3D ).

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