Non-Melanoma Skin Cancer: A Genetic Update and Future Perspectives.

Cancers (Basel) · 2022 · PMC9139429 · PMID 35625975

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An orthotopic model of skin SCC showed the lack of expansion of cancer-associated fibroblasts (CAFs) due to NOTCH1 gene silencing, without affecting the integrity of normal fibroblasts, and this may be significant for patients with a higher risk of skin carcinomas because of immune-suppressive therapies [ 37 ].

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