Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21.

Genes encoding proteins essential for lipid synthesis (e.g., Fasn (fatty acid synthase), Agpat (1-acylglycerol-3-phosphate O-acyltransferase 1) and Pdk4 (pyruvate dehydrogenase kinase, isoenzyme 4)) exhibited a partially significant increase in female SAT, whereas no change was detected in males, with the exception of Fasn, which was surprisingly significantly decreased ( Figure 4 B).

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