Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma.

Calculating the slope of the cell index that reflected the proliferation dynamics over time revealed a dose-dependent and highly significant decline to almost zero which came after incubation with the rising concentrations of Thio-Iva and Thio-Dam, both in Huh-7 ( Figure 3 b) as well as in SNU-449 ( Figure 3 d) cells, thus impressively showing the antiproliferative effect of both compounds.

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