As shown in Figure 4 , the evolution trend of the synonymous codon of histidine and arginine showed a decreasing trend of GC content at the third base.
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Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution.
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Phylogeny and MJ-Network Linear Genetic Evolution of SVA The pathogenicity and infection rate of the virus showed an increasing trend, which indicates that SVA underwent a dramatic genetic variation compared with the strains isolated earlier.