A Contemporary Insight of Metabolomics Approach for Type 1 Diabetes: Potential for Novel Diagnostic Targets.

Diabetes Metab Syndr Obes · 2022 · PMC9148614 · PMID 35642181

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an elevated trendno p-value reported

9 , 50 , 52 Inositol, a substance that can respond to renal tubular dysfunction and renal cell stress, showed an elevated trend.

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a decreasing trendno p-value reported

Interestingly, the decline in sphingomyelin in infancy leads to the first production of the GADA antibody, and diglycerides (DG), LPC and TGs all showed a decreasing trend before the production of GADA. 26 Hence, the liposome metabolome, which is involved in various metabolic pathways, has been confirmed to be an important factor affecting the formation of autoimmunity and the occurrence and development of T1D.

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