Orphan Drug Use in Patients With Rare Diseases: A Population-Based Cohort Study.

Front Pharmacol · 2022 · PMC9148958 · PMID 35652051

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a decreasing trendno p-value reported

Conversely, an overall greater intensity of use was found for deferoxamine, although with a decreasing trend since 2015.

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an increasing trendno p-value reported

In our study, icatibant showed an increasing trend from 2011 to 2014 followed by an almost steady prevalence (range 28.6–35.3%) until the end of the study period ( Figure 4A ).

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