Features of Epstein-Barr Virus and Cytomegalovirus Reactivation in Acute Leukemia Patients After Haplo-HCT With Myeloablative ATG-Containing Conditioning Regimen.

Risk Factors for Viral Reactivation In the univariate analysis, male patients [HR = 1.824, 95% CI (1.129–2.946), P = 0.014] and CMV reactivation [HR = 3.751, 95% CI (2.369–5.941), P < 0.001] had a significant association with EBV reactivation in the AML group, while acute GVHD had a statistical trend [HR = 1.602, 95% CI (0.985–2.605), P = 0.057] ( Table S1 ).

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Chronic GVHD [HR = 3.028, 95% CI (1.020–8.988), P = 0.046] and CMV reactivation [HR = 2.069, 95% CI (1.289–3.319), P = 0.003] were associated with EBV reactivation after HCT in the ALL group ( Table S3 ), EBV reactivation [HR = 1.979, 95% CI (1.205–3.250), P = 0.007] was associated with CMV reactivation, while chronic GVHD [HR = 2.939, 95% CI (0.863–10.007), P = 0.085] had a marginal significance ( Table S4 ).

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