Early and Late Transcriptional Changes in Blood, Neural, and Colon Tissues in Rat Models of Stress-Induced and Comorbid Pain Hypersensitivity Reveal Regulatory Roles in Neurological Disease.

The observed correlation in the expression of these genes reflected a highly significant functional interaction of their proteins; in fact, Search Tool for the Retrieval of Interacting Genes/Proteins detected 66 protein-protein interactions compared to the expected 5 (PPI, P ≤ 1.0e-16) ( Supplementary Figure 16 ) and reported high enrichment in the oxidative phosphorylation biological process (adj P = 1.1e-09).

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