CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.

Although there was an overall trend toward lower engraftment of LPS-stimulated HSPCs isolated from either LeprCre;Il6 fl/fl or control mice, this difference only reached statistical significance at the early 4-week posttransplant time point.

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Moreover, highly significant LPS-induced Il6 expression was noted in non-hematopoietic BM green fluorescent protein (GFP) + cells from Cxcl12-GFP and LeprCre;GFP transgenic mice that have been shown to specifically target CAR cells 12,14 ( Figure 1E-F ), corroborating the validity of our FACS-based isolation method.

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