Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.

Acta Neuropathol Commun · 2022 · PMC9153212 · PMID 35642016

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hedged sentence

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

marginal significancep value = 0.056so close (0.05 < p ≤ 0.1)

To further investigate this observation, we analyzed a larger cohort of published data [ 21 ] and found that the number of clones in a tumor sample was lower in H3.1-mutant cases with marginal significance (median 4.5 in H3.1 versus 6.0 in H3.3-mutant patients, p value = 0.056).

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