A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.

PLoS Pathog · 2022 · PMC9154123 · PMID 35584177

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highly significantp < 0.0001actually significant

Heat killed parasites failed to induce IFNλ at any timepoint assessed, and at 72 hours post infection, the difference in IFNλ production compared to controls was highly significant ( Fig 3A , p < 0.0001, Two-way ANOVA).

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