Interestingly, as shown in the heatmaps the NRF2 pathways genes showed an overall trend of downregulation upon EHF overexpression in both A253 and SCC25 cells, and increased expression in CAL-27 cells following the loss of EHF (Figure 7B ).
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EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC.
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