DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors.

Front Cardiovasc Med · 2022 · PMC9162507 · PMID 35665255

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may not be significantno p-value reported

Researchers in favor of suspending the total-effect test argue that requiring a significant total effect of the exposure on the outcome may limit the power of mediation analysis, since there are several scenarios in which the total effect may not be significant even in the presence of mediation.

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