PragmaTic, prospEctive, randomized, controlled, double-blind, mulTi-centre, multinational study on the safety and efficacy of a 6% HydroxYethyl Starch (HES) solution versus an electrolyte solution in trauma patients: study protocol for the TETHYS study.

Trials · 2022 · PMC9164328 · PMID 35655234

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a favorable trendno p-value reported

Recent meta-analyses of studies assessing the risk of renal impairment after HES administration, including those performed in trauma patients, have not shown significant differences in postoperative mortality and kidney disfunction [ 26 , 27 ], but a favorable trend towards a reduced hospital length of stay and lower vasopressors requirements for hemodynamic stability during resuscitation in patients treated with HES.

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