α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function.

Student’s t -test or one-way analysis of variance followed by Tukey’s post-hoc test was used for analysis, p < 0.05 (*) was considered significant, p < 0.01 (**) was considered highly significant, and p < 0.001 (***) was very highly significant.

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3 A, B, D, the ZO-1, claudin-1 and JAM-1 proteins expressions in intestinal tissues of DSS-induced colitis mice significantly decreased, while occludin protein only showed a decreasing trend (Fig. 3 C).

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