Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases.

Proc Natl Acad Sci U S A · 2022 · PMC9169777 · PMID 35385357

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Extending the leukemogenesis model of MPAL, we deduced that genetic lesions might occur at an earlier HSPC stage in adult T-ALL, resulting in abnormal proliferation/differentiation/apoptosis of myeloid and lymphoid lineages, which might be significant in explaining the difference in prognosis and treatment responses observed between pediatric and adult T-ALL ( SI Appendix , Fig.

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