Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.

Nat Commun · 2022 · PMC9170782 · PMID 35668129

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highly significantno p-value reported

Pathway analysis was performed and indeed IFN-γ was the most highly significant predicted upstream cytokine regulator of Mac SAR-1 clusters based on their transcriptional profile ( Fig. 4j ) and consistent with the upregulation of IFNG observed in CD4 + T cells in sarcoidosis.

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