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Trends in Cannabis Polysubstance Use During Early Pregnancy Among Patients in a Large Health Care System in Northern California.

JAMA Netw Open · 2022 · PMC9171564 · PMID 35666502

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an increasing trendno p-value reported
45 , 46 However, our sensitivity analysis found an increasing trend of prenatal cannabis and illicit or unauthorized pharmaceutical opioid rates, reflecting increases in co-use of cannabis with pharmaceutical opioids that were not prescribed by a medical professional (eg, via medication diversion).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.