H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer.

Proc Natl Acad Sci U S A · 2022 · PMC9173765 · PMID 35584120

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closest p · 0.0× alpha

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highly significantP = 1.3 × 10 −5actually significant

Supporting our in vitro findings, analysis of REs in metastatic CRPC tumors revealed a highly significant negative correlation ( r = −0.697, P = 1.3 × 10 −5 ) between levels of SUV39H1/H2 and MDA5-binding repeat RNAs in patients exposed to the antiandrogens Enz or abiraterone ( Fig. 5 C ).

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