Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT.

J Atheroscler Thromb · 2022 · PMC9174092 · PMID 33867420

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marginal significanceno p-value reported

Therefore, the primary and secondary endpoints were opposite in these two trials. When these two trials were combined and an integrated analysis was performed, probucol was demonstrated to reduce cerebrocardiovascular events in patients with CAD, with marginal significance.

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