Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.

However, the electrostatic effect may be significant if the linker was short as in the case of H 2 NCH 2 -γ-PNA whereby the duplex stability was higher than in the case of the amino-modified γPNA with longer linkers ( Table 5 ). 48,50,51 Interestingly, γPNA with the negatively charged –CH 2 SO 3 − substituent adopted a more extended conformation in the single-stranded form as shown by NMR and CD analyses which could be due to the intra-strand electrostatic and steric interactions among the sulfate groups.

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