Predictability of Nonremitting Depression After First 2 Weeks of Antidepressant Treatment: A VAST-D Trial Report.

While the data showed only a nonsignificant trend in the direction of early medication change providing a better outcome, a major confounding issue in the Tadić et al. study was that more patients in the treatment‐as‐usual group ultimately received the alternative intervention, venlafaxine, than those who had been allocated to switch to venlafaxine.

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