Temporary cessation of ibrutinib results in reduced grade 3-4 infections and durable remissions-Interim analysis of an on-off-repeat Phase 1b/2 study in patients with chronic lymphocytic leukemia.

EJHaem · 2021 · PMC9176042 · PMID 35844699

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a positive trendno p-value reported

A preplanned early interim analysis was scheduled after 20 included patients; the number was based on our previous experience on explorative studies to provide an indicator that no safety signals emerged and that outcome measures showed a positive trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.