Comparative transcriptome analysis of quadriceps muscles of miR-1/133a dKO and miR-1/206/133 tKO in combination with gene set enrichment analysis (GSEA) revealed a highly significant enrichment of potential miR-1/206 and miR-133 target genes in miR-1/133/206 tKO muscles (Fig. 1f, g ).
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Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function.
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