The parent study also found treatment of initial CDI with metronidazole versus vancomycin to be associated with recurrence; this association was only borderline significant ( p = 0.12) in the subset of patients analyzed for our multi-omic study, likely due to the smaller sample size.
RF also identified features with borderline significance that were found in the univariate analyses, including sphingomyelins, primary bile acids, and a phosphorylated lipid (Fig. 5 ).
We deem features significant if the 95% cross-validated odds-ratio/feature-importance intervals did not contain 1.0, and marginally significant if the 75% cross-validated interval did not contain 1.0.