Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms.

In the summary of the analysis data from the 24 h time point linked to neurological function ( Supplementary Figure 2 ), APP was now linked with 20 different proteins, and GO Cellular Component terms enriched included “synapse, neuron projection, spliceosomal complex, cell junction, mitochondrial, and actin cytoskeleton.” GO biological processes had highly significant categories of “modulation of excitatory post synaptic potential,” “membrane biogenesis, regulation of exocytosis, regulation of actin filament polymerisation, and regulation of RNA splicing.” To tease out functionally important interactions with APP, a STRING diagram associated with “Neuronal projection” and “Synapse” GO terms were generated to observe how they interacted with each other and the experimental effector protein sAPPα (as APP).

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