modestly significantp = 0.031
Treatment worked better the more readily cells could replace their neighbors for all protocols ( p < 0.01 and HR ≤ 0.83), with only two exceptions: for DM Ping-Pong Alternate Every Cycle, there was no significant difference between 50% and 100% replacement ( p = 0.275), and for DM Ping-Pong on Progression, that difference was only modestly significant, though still with a large effect size (HR = 0.40 [0.17–0.92], p = 0.031).