Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart.

J Mol Cell Cardiol · 2021 · PMC9181638 · PMID 34273410

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not yet significantno p-value reported

The majority of these changes in chromatin accessibility in the early phase are not yet significant, but the direction of change is determined by this time and continues into late pathology.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.