Although virus suppression in CpA-Dcr2 and CpA-R2d2 transgenic mosquitoes was highly significant, the leaky infection phenotype we observed warrants further study as part of the development of mosquitoes that are highly resistant to multiple viruses.
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The Aedes aegypti siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses.
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