Neutralising reactivity against SARS-CoV-2 Delta and Omicron variants by vaccination and infection history.

Antibody dynamics in vaccinated and unvaccinated subjects Among vaccinated subjects, independently of the number of doses received, we found a significant increase of both DiaSorin and neutralisation titres (Friedman test followed by Dunn’s multiple comparisons P < 0.0001 for both cases), with all subjects showing an increasing trend; on the contrary, in the unvaccinated group, antibodies directed against the S antigen decreased significantly, as measured by DiaSorin and neutralisation (Friedman test followed by Dunn’s multiple comparisons test from November 2020 to June 2021 P < 0.01 for both cases) (Fig. 2 ).

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