Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.

Curr Neuropharmacol · 2021 · PMC9185784 · PMID 33573557

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an interesting trendno p-value reported

reported that the risk of major malformations associated with polytherapy is primarily influenced by VPA and found an interesting trend towards a lower rate of malformations in the VPA + other AEDs group (19.2%) compared to VPA monotherapy (24.0%) for the highest VPA doses (≥1,500 mg/day) [ 59 ].

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