25 Chemotherapy may cause irreversible ovarian damage, so the fertility preservation of women of childbearing age and adolescent women during the anticancer period is extremely significant. 6 However, fertility preservation methods recommended by the American Reproductive Medicine Association are to preserve the couples' embryos and the female oocytes. 26 Although hormone replacement therapy can be used for a long time to relieve symptoms, it can not prevent its occurrence and progress. 27 Besides, ovarian tissue transplantation and stem cell transplantation can not cure POI, due to their poor prognosis and uncontrollable long‐term results. 28 Therefore, it is urgent to find a new clinical treatment strategy for POI patients.
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miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9.
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