marginally significantp < 0.10
The marginally significant inverse relationship between HbA1c and all-cause mortality observed when δNfL is set at its mean (CDE < 0, p < 0.10) becomes non-significant when δNfL is not fixed in the total population with this difference in effect caused by pure interaction as well as mediated interaction (IR > 0, IM > 0, p < 0.05), indicative of synergism between HbA1c and δNfL in determining mortality risk.