Case Report: Afatinib Sensitivity in Rare EGFR E746_L747delinsIP Mutated LUAD With Peritoneal Metastases.

During the treatment, the patient’s chest symptoms were relieved, and simultaneously, CA125 and CYFRA21-1 showed a decreasing trend, especially CA125 ( Figure 3 ); however, the peritoneal effusion with a chylous appearance continued to increase ( Figure 1G2 ), requiring drainage of 1000–1500 ml per day.

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Follow-up CT until April 2022 showed that the pulmonary lesions were slightly enlarged, bilateral pulmonary nodules were increased, abdominal nodules continued to be stable, and the curative effect assessment of lesions primarily showed an increasing trend within the stable disease (SD) range ( Figures 1I1, I2 ).

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