Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.

Autophagy · 2022 · PMC9196656 · PMID 35287553

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highly significantno p-value reported

Importantly, the treatment with recombinant proCTSD mediated highly significant effects in vitro , as it reduced pathological SNCA conformers and corrected intracellular pathways as well as in vivo it improved behavioral outcome [ 47 ].

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